Interleukin‐1 Receptor Antagonist Gene Polymorphism, Infectious Burden, and Coronary Artery Disease
نویسندگان
چکیده
منابع مشابه
Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease.
BACKGROUND Cytokine gene variations are contributory factors in inflammatory pathology. Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A(-889), IL-1B(-511), IL-1B(+3953), IL-1RN Intron 2 VNTR] and tissue necrosis factor (TNF)-alpha gene [TNFA(-308)] were measured in healthy blood donors (healthy control subjects), patients with angiographically normal coronary arteries (patient con...
متن کاملInterleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease.
BACKGROUND Coronary Artery Disease (CAD) is the atherosclerosis of coronary arteries that carry blood to the heart muscle. Atherosclerosis is an inflammatory disease. Cytokine gene variations such as those associated with the IL1 family are involved in the pathogenesis of atherosclerosis. OBJECTIVE The purpose of this study was to determine the relationship between IL1 family polymorphisms (I...
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Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with coronary artery disease (CAD) and normal subjects. The corr...
متن کاملACE Gene Polymorphism and Coronary Artery Disease
Great personal enthusiasm, temptation, technical efforts, and complex mathematical equations characterize the developing research field of newly identified gene polymorphisms and their impact on a variety of cardiovascular diseases. After the first publication of Cambien and coworkers1 in Nature in 1992, who reported that the D/D angiotensinconverting enzyme (ACE) polymorphism is a potent risk ...
متن کاملPrognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease
BACKGROUND Chronic inflammatory stimuli such as cytomegalovirus (CMV) infection and various genetic polymorphisms determining the inflammatory response are assumed to be important risk factors in atherosclerosis. We investigated whether patients with stable coronary artery disease (CAD) and homozygous for allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene and seropositive for CMV r...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2002
ISSN: 1058-4838,1537-6591
DOI: 10.1086/340531